Stereospecific Effects of (–)- and (+)-7-Hydroxy-Delta-6-Tetrahydrocannabinol-Dimethylheptyl on the Immune System of Mice

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Abstract
The effects of the (+) and (-) canabinoid enantiomers 7-hydroxy-delta-6-tetrahydrocannabinol-dimethylheptyl [(-)-7-OH-delta-THC-DMH (HU-210) and (+)-7-OH-delta-6-THC-DMH (HU-211)] on the inductive and productive phases of the primary humoral immune response to sheep red blood cell immunization were investigated in mice. Animals treated with (-)-7-OH-delta-6-THC-DMH (0.01, 0.05, 0.1 and 0.5 mg/kg) exhibited a dose-dependent suppression of both phases of the primary humoral immune response in the hemolytic plaque assay, the hemagglutination titer and in the ratio of the spleen weight to final body weight. Mice treated with (=)-7-OH-delta-6-THC-DMH (0.01, 0.05, 0.1, 0.5 and 1.0 mg/kg) did not exhibit dose-dependent immune suppression. However, the (+) enantiomer reduced the number of plaque-froming cells in the hemolytic plaque assay during the inductive phase. Mice treated with a combination of (-) and (=) enantiomers, each at 0.01 mg/kg, exhibited no impairment in ability to undergo a primary humoral immune response (inductive phase).