EFFECT OF INDOMETHACIN ON RENAL BLOOD-FLOW AND URETERAL PRESSURE IN UNILATERAL URETERAL OBSTRUCTION IN AWAKE DOGS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 15  (4) , 324-327
Abstract
In the conscious dog, the effect of administering indomethacin before and throughout an 8 h period of unilateral ureteral occlusion was determined. Before ureteral occlusion, indomethacin infusion caused a 35%-40% decrease in bilateral renal blood flow. After ureteral occlusion, the characteristic ipsilateral renal vasodilation did not occur and the ureteral pressure rose only to a maximum of 18 mmHg and remained significantly lower (P < 0.05) than pressures in control animals during the entire study period. Pathways for renal synthesis of prostaglandins must be intact for renal vasodilation to occur in response to ureteral occlusion.

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