Metabolism of N-acetyl-l-cysteine Some structural requirements for the deacetylation and consequences for the oral bioavailability
- 20 November 1989
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 38 (22) , 3981-3985
- https://doi.org/10.1016/0006-2952(89)90677-1
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- The metabolism of35S-D-penicillamine in manXenobiotica, 1988
- Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteineEuropean Journal of Clinical Pharmacology, 1988
- Gastrointestinal metabolism of N‐acetylcysteine in the rat, including an assay for sulfite in biological systemsBiopharmaceutics & Drug Disposition, 1987
- Possible Physiological Roles of Carboxylic Ester HydrolasesDrug Metabolism Reviews, 1987
- Theory of complex molecular interactions: computer graphics, distance geometry, molecular mechanics, and quantum mechanicsAccounts of Chemical Research, 1985
- Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In VivoJournal of Clinical Investigation, 1983
- Molecular mechanics studies of enzyme-substrate interactions: the interaction of L- and D-N-acetyltryptophanamide with α-chymotrypsinJournal of the American Chemical Society, 1983
- Computation of peptide-protein interactions. Catalysis by chymotrypsin: prediction of relative substrate reactivitiesJournal of the American Chemical Society, 1981
- Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.BMJ, 1979
- Enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other speciesJournal of Toxicology and Environmental Health, 1976