Regulation of p85α phosphatidylinositol‐3‐kinase expression by peroxisome proliferator‐activated receptors (PPARs) in human muscle cells
- 3 August 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 502 (3) , 98-102
- https://doi.org/10.1016/s0014-5793(01)02674-6
Abstract
Regulation of p85a phosphatidylinositol-3-kinase (p85alphaPI-3K) expression by peroxisome proliferator-activated receptor (PPAR) activators was studied in human skeletal muscle cells. Activation of PPARgamma or PPARbeta did not modify the expression of p85alphaPI-3K. In contrast, activation of PPARalpha increased p85alphaPI-3K mRNA. This effect was potentiated by 9-cis-retinoic acid, an activator of RXR. Up-regulation of p85alphaPI-3K gene expression resulted in a rise in p85alphaPI-3K protein level and in an increase in insulin-induced PI3-kinase activity. According to the role of p85alphaPI-3K in insulin action, these results suggest that drugs with dual action on both PPARgamma and PPARalpha can be of interest for the treatment of insulin resistance.Keywords
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