Localization of Cyclic GMP and Cyclic AMP in Cardiac and Skeletal Muscle: Immunocytochemical Demonstration
- 14 January 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4274) , 183-185
- https://doi.org/10.1126/science.188135
Abstract
When rat cardiac and skeletal muscle are explored by immunocytochemical procedures designed to show sites of localization of adenosine 3′,5′-monophosphate (cyclic AMP) and guanosine 3′,5′-monophosphate (cyclic GMP), distinct staining patterns for the two nucleotides are seen. Antibody to cyclic AMP is found in the area of the sarcoplasmic reticulum, while antibody to cyclic GMP is found with a periodic distribution corresponding to that of the A band. This suggests a role for cyclic GMP in the regulation of myosin.This publication has 19 references indexed in Scilit:
- Surface Modulation in Cell Recognition and Cell GrowthScience, 1976
- Neurotransmitters Increase Cyclic Nucleotides in Postganglionic Neurons: Immunocytochemical DemonstrationScience, 1975
- Cyclic Guanosine and Adenosine 3′,5′-Monophosphates in Canine Thyroid: Localization by ImmunofluorescenceScience, 1974
- Myosin light‐chain kinase, a new enzyme from striated muscleFEBS Letters, 1974
- Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction CycleScience, 1973
- Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycleBiochemical and Biophysical Research Communications, 1973
- Cyclic adenosine 3′,5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomesJournal of Molecular and Cellular Cardiology, 1972
- A METHOD FOR DETECTING INTRACELLULAR CYCLIC ADENOSINE MONOPHOSPHATE BY IMMUNOFLUORESCENCEJournal of Histochemistry & Cytochemistry, 1972
- Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with AcetylcholineProceedings of the National Academy of Sciences, 1970
- RADIOIMMUNOASSAY FOR THE MEASUREMENT OF ADENOSINE 3′,5′-CYCLIC PHOSPHATEProceedings of the National Academy of Sciences, 1969