Systemic sclerosis-like lesions during long-term penicillamine therapy for Wilson's disease
- 1 January 1987
- journal article
- case report
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 116 (1) , 95-100
- https://doi.org/10.1111/j.1365-2133.1987.tb05795.x
Abstract
Systemic sclerosis‐like lesions developed in a 14‐year‐old boy with Wilson's disease who had been treated with D‐penicillamine for 11 years. Clinical and laboratory manifestations included proximal scleroderma, pulmonary restrictive defects, positive antinuclear antibodies, and the deposition of C3 at the dermal‐epidermal junction of the lesional skin. This is the first case reported in which long‐term administration of penicillamine was followed by the development of systemic sclerosis‐like lesions.Keywords
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