Co-expression of Nicastrin and Presenilin Rescues a Loss of Function Mutant of APH-1
Open Access
- 3 September 2004
- journal article
- Published by Elsevier
- Vol. 279 (36) , 37311-37315
- https://doi.org/10.1074/jbc.m406228200
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generationThe EMBO Journal, 2004
- Alzheimer's Disease Is a Synaptic FailureScience, 2002
- Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic ProteaseScience, 2002
- Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteasesNature Cell Biology, 2000
- Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processingNature, 2000
- Aβ-Generating EnzymesNeuron, 2000
- Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cellsNature Cell Biology, 2000
- Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1Nature Cell Biology, 2000
- Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1Nature, 2000
- Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activityNature, 1999