Beta-alanine synthesis in Escherichia coli
- 1 March 1980
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 141 (3) , 1291-1297
- https://doi.org/10.1128/jb.141.3.1291-1297.1980
Abstract
The enzyme, aspartate 1-decarboxylase (L-aspartate 1-carboxy-lyase; EC 4.1.1.15), that catalyzes the reaction aspartate .fwdarw. .beta.-alanine + CO2 was found in extracts of E. coli, panD mutants of E. coli are defective in .beta.-alanine biosynthesis and lack aspartate 1-decarboxylase. Therefore, the enzyme functions in the biosynthesis of the .beta.-alanine moiety of pantothenate. The genetic lesion in these mutants is closely linked to the other pantothenate (pan) loci of E. coli K-12.This publication has 41 references indexed in Scilit:
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