The Effect of X-Ray Irradiation Upon the Mandibles of Guinea Pigs Treated With Large and Small Doses of Ascorbic Acid

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Abstract
X-ray irradiation lesions were studied histologically in the bone and incisors of the mandibles of young guinea pigs which received large (50 mg. every other day) or small (1 mg. every other day) doses of ascorbic acid. It was found that (1) with exposure to 1200 r, 2600 r, and 4200 r generated by 143 kv., the reduction of bone deposition and osteoradiolysis in the mandibles of animals with large ascorbic acid doses were less pronounced than in animals with small doses of ascorbic acid, notwithstanding the similarity of histologic structure of bone developed before the irradiation in both groups of guinea pigs. (2) In animals with large doses of ascorbic acid, with dosages of 2600 r and 4200 r the dentinoblasts were still active in production of regular dentin. (3) In animals with small doses of ascorbic acid, 800 r and 1200 r dosages of X-ray disturbed the function of scorbutically changed dentinoblasts still more. With dosages of 2600 r and 4200 r total disintegration of dentinoblasts and pulp cells took place, accompanied by circulatory disturbances of pulp. (4) In animals with large ascorbic acid doses the osteoblasts appeared more radiosensitive than the osteocytes, and the osteocytes, in their turn, more radiosensitive than mature dentinoblasts. (5) In animals with small ascorbic acid doses the scorbutically changed dentinoblasts appeared to be more radio-sensitive than the osteoblasts and osteocytes.

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