PULMONARY-FUNCTION AND BRONCHIAL REACTIVITY IN HUMAN-SUBJECTS WITH EXPOSURE TO OZONE AND RESPIRABLE SULFURIC-ACID AEROSOL

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Abstract
The effect of 0.3 ppm O3 with a subsequent exposure to 100 .mu.g/m3 H2SO4 aerosol was studied in 12 nonsmoking subjects to determine if preexposure to O3 would sensitize them to H2SO4 aerosol. Pulmonary function and bronchial reactivity measurements were made after single and sequential exposures to these pollutants. No significant changes in pulmonary function or bronchial reactivity to methacholine were observed. A decrease in bronchial reactivity approaching significance occurred after the 4 h exposure to 100 .mu.g/m3, 0.13 .mu.m H2SO4 aerosol. There were no readily apparent risks from sequential exposures of nonsmokers to low concentrations of O3 and H2SO4 aerosol during light-to-moderate exercise.