Additive Effects Shown by Combinations of Nitroxyl and Electron-Affinic Hypoxic Cell Sensitizers

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Abstract
Nitroxyl free radical sensitizers enhance the radiation killing of Escherichia coli K12 RecA- to a greater extent than does O2. Unlike O2, electron-affinic sensitizers of the nitro-aromatic type cannot compete to reduce this superoxic level of sensitization. Instead, the 2 types of sensitizer, when used in combination, are additive in their effect on reducing the survival of E. coli K12 RecA-, suggesting that they operate on different types of radiation-induced lesion. Experiments with other E. coli strains show similar effects.