2(3H)- and 2(5H)-Furanones. III. An Efficient Synthesis and the Eschenmoser-Mannich Reaction of N-Substituted 4-Amino-2(5H)-furanones
- 1 January 1988
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 27 (8) , 1907-1923
- https://doi.org/10.3987/com-88-4594
Abstract
A series of N-substituted 4-amino-2(5H)-furanones (II) was derived from .beta.-tetronic acid (I) by direct action of several aliphatic and aromatic amines. The Eschenmoser-Mannich reaction of II readily gave the corresponding Mannich bases (VI) quantitatively.Keywords
This publication has 3 references indexed in Scilit:
- Synthesis of 3‐formyltetronic acid and enamine derivativesJournal of Heterocyclic Chemistry, 1981
- Structure-activity relationships in tetronic acids and their copper(II) complexes.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979
- Synthesis of 4-substituted tetronic acids: multicolanic acidJournal of the Chemical Society, Chemical Communications, 1979