A Novel and Highly Regioselective Approach to 5-Methoxy-6-substituted-3-sulfonyl-δ-enlactams from 5-Methoxy-3-sulfonyl Glutarimide: Synthesis of cis-2-Substituted-3-piperidinols

Abstract
A convenient method for the preparation of 5-methoxy-6-substituted-3-sulfonyl-delta-enlactams via regioselective nucleophilic addition to 5-methoxy-3-sulfonyl glutarimide is described. Formal syntheses of L-733,060, CP-99,994, and cassine are also reported.

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