PHARMACODYNAMICS OF THE DIURETIC EFFECTS OF AMINOPHYLLINE AND ACETAZOLAMIDE ALONE AND COMBINED WITH FUROSEMIDE IN NORMAL SUBJECTS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 227  (1) , 92-97
Abstract
Normal subjects were used to assess the mechanism of the natriuretic effects of aminophylline, to confirm the effect of acetazolamide on the proximal tubule and to assess the pharmaodynamics on the combination of aminophylline and of acetazolamide with furosemide. None of these agents or their combination affected renal hemodynamics. Aminophylline inhibited solute reabsorption at the diluting segment manifested by a 15% decrease in free water clearance relative to solute delivery (P < 0.001). It also decreased solute reabsorption in the proximal nephron. Acetazolamide affected only the proximal tubule. The combination of either aminophylline or acetazolamide with furosemide was little different from furosemide alone. Analysis of dose-response curves to furosemide revealed a minor additive, i.e., parallel upward shift, of the dose-response curves with both combinations.