BLOOD PLASMA IN MULTIPLE SCLEROSIS

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Abstract
IN A PREVIOUS investigation Swank, Franklin, and Quastel1 found that the plasma protein pattern in paper chromatograms may be abnormal during exacerbations of multiple sclerosis. During remission the plasma protein pattern returns to normal. Using the ultracentrifuge, Aird, Gofman, Jones, Campbell, and Garoutte2 observed the presence of abnormal plasma lipoprotein fractions during activity of the disease. The fact that these abnormal lipoproteins occurred during exacerbations suggests that they are in some way related to the previous observation of Swank, Franklin, and Quastel.1 However, no decision is yet justified. The purpose of the present paper is to demonstrate the normal paper chromatogram and its changes when studied frequently over long periods of time in normal human subjects, and in patients with multiple sclerosis during periods both of activity and of relative inactivity of the disease. MATERIAL AND METHODS Blood samples were obtained from fasting patients and fasting normal

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