EFFECTS OF THE REMOVAL OF THE ANTERIOR LOBE OF THE HYPOPHYSIS ON SOME RENAL FUNCTIONS

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Abstract
Renal function studies on 12 dogs are reported. 6 of the dogs had a total hypophysectomy, 4 a simple hypophysectomy and 2 denervation of the entire neuro-hypophysis with preservation of the ant. lobe. D and inulin plasma clearances and DTm were detd. in all dogs before and at intervals after operation for 9 mos. to a yr. In some of the animals D and inulin extractions were detd. on explanted kidneys. D and inulin plasma clearances and DTm were markedly decreased by loss of the ant. lobe of the hypophysis. D and inulin extractions at low plasma levels were unaffected. Loss of the pitressin forming tissue did not affect these renal functions. The decrease in D and inulin plasma clearances was attributed to a decrease in renal plasma flow. The decrease in DTm was due not only to the decrease in renal blood flow but also to a depression of the functional capacity of the tubules to transport D at high plasma levels. Loss of the ant. lobe of the hypophysis or loss of the entire hypophysis did not result in a diminution of blood vol. when the calculations were made on the basis of the original wts. of the animals. If the dogs became obese because of the nature of the operation to which they were subjected the blood vol. calculated on the basis of actual wt. at the time of the observation showed a decrease averaging 50% of the % increase in body wt. Loss of the anterior lobe of the hypophysis did not result in glomerular intermittence.