Organic Chemistry in Drug Discovery
- 19 March 2004
- journal article
- special viewpoints
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5665) , 1810-1813
- https://doi.org/10.1126/science.1096800
Abstract
The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.Keywords
This publication has 7 references indexed in Scilit:
- Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and DevelopmentChemical Research in Toxicology, 2003
- Screening for the potential of a drug candidate to cause idiosyncratic drug reactionsDrug Discovery Today, 2003
- Cassette‐accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discoveryRapid Communications in Mass Spectrometry, 2001
- Screening lead compounds for QT interval prolongationDrug Discovery Today, 2001
- Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor AntagonistJournal of Medicinal Chemistry, 1998
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) ReceptorScience, 1991