Genetic Characterization of Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Isolated during Ciprofloxacin Therapy from a Patient with Bronchiectasis
Open Access
- 1 April 2003
- journal article
- case report
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (4) , 1419-1422
- https://doi.org/10.1128/aac.47.4.1419-1422.2003
Abstract
Five Spain 9V-3 Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.Keywords
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