Effects of Oral and Intracecal Pectin Administration on Blood Lipids in Minipigs
- 1 January 1986
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 116 (1) , 70-76
- https://doi.org/10.1093/jn/116.1.70
Abstract
The effects on blood lipids of oral and intracecal pectin administration for 4 wk were examined in six male adult hypercholesterolemic minipigs (total serum cholesterol = 8.4 mmol/L). The pigs were fitted with a cecal cannula and were assigned to three groups of two pigs each; the groups underwent an experiment in 3 × 3 Latin square design. The control period was designated as that during which water was infused into the cecum. Total serum cholesterol concentration was about 50% lower after feeding 75 g pectin per day than during the control period. The intracecal infusion of the same amount of pectin had no effect on total serum cholesterol concentration compared to the control period. The cholesterol level in the low density lipoproteins (LDL), in the very low density lipoproteins (VLDL) and in the high density lipoproteins (HDL) was lower after feeding pectin than in the control period. The HDL cholesterol, but not LDL or VLDL cholesterol, was at a lower level after intracecal infusion of pectin than during the control period. Thus, the study clearly demonstrates that the passage of pectin through the small intestine is necessary for its hypocholesterolemic action.Keywords
This publication has 36 references indexed in Scilit:
- Blut- und Serumwerte des Göttinger Miniaturschweines*Zentralblatt für Veterinärmedizin Reihe A, 1982
- INFLUENCE OF PROPIONIC ACID ON THE CHOLESTEROL METABOLISM OF PIGS FED HYPERCHOLESTEROLEMIC DIETSCanadian Journal of Animal Science, 1981
- EFFECTS OF DIETARY PROPIONIC ACID ON SERUM LIPIDS AND LIPOPROTEINS OF PIGS FED DIETS SUPPLEMENTED WITH SOYBEAN MEAL OR CANOLA MEALCanadian Journal of Animal Science, 1981
- Mechanism of action of dietary fibre in the human colonNature, 1980
- DIETARY FIBRE, DIABETES, AND HYPERLIPIDÆMIAThe Lancet, 1979
- The digestion of pectin in the human gut and its effect on calcium absorption and large bowel functionBritish Journal of Nutrition, 1979
- Short chain fatty acid absorption by the human large intestine.Gut, 1978
- Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feedingBiochemistry, 1975
- Can colonic bacterial metabolites predispose to cholesterol gall stones?BMJ, 1975
- Dietary pectin and plasma cholesterol in swineJournal of Atherosclerosis Research, 1966