THE EFFECTS OF ALDOSTERONE AND OTHER STEROIDS ON WATER INTOXICATION AND RENAL FUNCTION

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Abstract
Adrenalectomized rats were used to study the effects of various steroids on the experimental syndrome of water intoxication and on creatinine and paraaminohippurate clearance and urine flow in mildly hydrated animals. Aldosterone and hydrocortisone provided about equal resistance to water intoxication, cortisone and corticosterone provided less, and desoxycorticosterone much less. At relatively high dose levels, aldosterone, hydrocortisone and cortisone were equally effective in elevating the clearances of creatinine and paraaminohippurate; at lower dose levels cortisone was inactive. Desoxycorticosterone was the weakest of the compounds studied in all respects and its dose-response curves were notably flat. All steroids stimulated water diuresis both in the water intoxication and in the renal clearance experiments. The amounts of aldosterone required to produce the various effects described were much larger than those needed to produce profound effects on electrolyte metabolism.

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