Reye syndrome
- 1 April 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 29 (4) , 467
- https://doi.org/10.1212/wnl.29.4.467
Abstract
Concentrations of homovanillic acid (HVA) were markedly elevated in the ventricular fluid of 15 children with Reye syndrome (median, 887 ng per milliliter) compared to 7 controls (median, 282 ng per milliliter), but 5-hydroxyindoleacetic acid (5-HIAA) values were comparable (medians of 198 and 189 ng per milliliter, respectively). The ratio of 5-HIAA to HVA was significantly lower in patients with Reye syndrome (0.26) than in controls (0.51). Serial samples demonstrated wide fluctuations in HVA concentration, but not in that of 5-HIAA. Monoamine metabolite concentrations were not correlated with serum ammonia, increased intracranial pressure, morbidity, or mortality. Increased HVA in Reye syndrome may reflect cerebral ischemia and release of vasoactive amines (particularly dopamine) into the brain and cerebrospinal fluid (CSF).This publication has 4 references indexed in Scilit:
- Catecholamine and octopamine concentrations in brains of patients with Reye syndromeNeurology, 1977
- Reye's Syndrome: Patient Serum Alters Mitochondrial Function and Morphology in VitroScience, 1977
- Prolonged Continuous Monitoring of Intracranial Pressure in Severe Reye's SyndromePediatrics, 1977
- Concentration of 3′, 5′ Cyclic Adenosine Monophosphate in Ventricular Cerebrospinal Fluid of Patients with Prolonged Coma after Head Trauma or Intracraneal HemorrhageNew England Journal of Medicine, 1976