INCIDENCE OF SEIZURES DURING TREATMENT WITH TRICYCLIC ANTI-DEPRESSANT DRUGS AND BUPROPION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (5) , 197-201
Abstract
The incidence of convulsions in patients receiving tricyclic antidepressants or bupropion was reviewed. For both types of drug, the risk of a seizure was dose-dependent and was higher in patients with predisposing factors, e.g., a history of seizures. Patients without a predisposing factor had a convulsion incidence of .apprx. 0.6-0.9% (6-9/1000 patients) when receiving imipramine at doses of > 200 mg/day or bupropion at doses > 450 mg/day. At lower doses, the frequency of seizures dropped to .apprx. 1/1000 for imipramine and bupropion. The risk of a seizure in patients receiving equally therapeutic doses of imipramine and bupropion appears to be comparable.

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