HLA and alveolar echinococcosis
- 1 August 1998
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 52 (2) , 124-129
- https://doi.org/10.1111/j.1399-0039.1998.tb02275.x
Abstract
Evidence in animal intermediate hosts that susceptibility to larval infection with Echinococcus multilocularis is restricted to individual host factors prompted us to investigate the susceptibility markers in humans. Because antigens of the extracellular parasite E multilocularis are possibly presented by MHC molecules in a restricted way, we speculated that MHC polymorphism may influence resistance of the host towards infection and course of disease. We studied HLA‐A, ‐B, ‐DRB1, ‐DQB1 and ‐DPB1 polymorphism in 151 patients with alveolar echinococcosis. Patients with an observation period of more than 2 years were grouped according to the clinical follow‐up into cured (no recurrence following surgery) patients and patients with regressive or progressive forms of disease during benzimidazole chemotherapy. By comparing phenotypic frequency between patients with alveolar echinococcosis and healthy controls, HLA‐DRB1*11 was associated with a reduced risk for disease development (odds ratio=0.55, 95% confidence interval=0.34–0.88; P=0.01). HLA‐DQB1*O2 was more frequent in patients with progressive disease when compared with patients with regressive disease (54.3% vs 28.3%, P=0.02). The result suggests that HLA‐DRB1*11 might confer protection against alveolar echinococcosis and that HLA‐DQB1*02 may indicate a risk for progressive disease development. The findings may facilitate the search for immunodominant T‐cell epitopes of E. multilocularis.Keywords
This publication has 42 references indexed in Scilit:
- Nomenclature for factors of the HLA system, update January/February 1997Human Immunology, 1997
- Nomenclature for factors of the HLA system, 1996Tissue Antigens, 1997
- The Nature of Selection on the Major Histocompatibility ComplexCritical Reviews in Immunology, 1997
- Protective immune mechanisms against the metacestode of Echinococcus multilocularisParasitology Today, 1995
- T-cell activation in HLA-B8,DR3-positive individuals early antigen expression defect in vitroHuman Immunology, 1995
- Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptideNature, 1994
- Common West African HLA antigens are associated with protection from severe malariaNature, 1991
- Soluble Interleukin-2 Receptor Secretion Defectin Vitroin HLA-B8, DR3 Positive SubjectsAutoimmunity, 1990
- GENETIC CONTROL OF SURVIVAL IN EPIDEMICSInternational Journal of Immunogenetics, 1979
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955