Hepatic Influence on Splenic Synthesis and Release of Coagulation Activities
- 14 November 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3907) , 882-883
- https://doi.org/10.1126/science.166.3907.882
Abstract
Isolated rabbit liver perfusates contain one or more puromycinsensitive factors that stimulate factor VIII and IX activities in splenic perfusates. Production of coagulation activity by a complementary process involving organ perfusates suggests existence of coagulation factor precursors. An analogy is made to appearance of high factor VIII activity after plasma transfusions in von Willebrand's disease.Keywords
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