Maze acquisition and retention in hypothermic mice

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Abstract
Three experiments were carried out to demonstrate the relation between learning and retention as affected by a reduction of colonic temperature in mice. Animals rendered hypothermic (T Ε = 3.3 C, 3.4 C) by treatment with 2,4-dichlorophenoxyacetic acid and exposure to cold air (2.0±0.5 C) did not acquire a simple escape response from a water maze within ten training trials. Saline-treated control animals demonstrated acquisition within four trials under similar conditions. Retention of the maze habit was a function of acquisition during training. Retention scores, as well as performance measures, were not affected by a comparable reduction in colonic temperature. Note: (With the Technical Assistance of J. R. Blumstein and D. Pennec) Submitted on January 22, 1962

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