A double‐blind placebo‐controlled study to compare the autonomic effects of fluvoxamine with those of amitriptyline and doxepin in healthy volunteers.

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Abstract
1 A double-blind placebo- and standard-controlled study was designed to determine the autonomic effects of fluvoxamine, a putative antidepressant possessing a high 5-hydroxytryptamine (5-HT) re-uptake-blocking activity with essentially no effects on noradrenaline. The study employed single doses of fluvoxamine (50 mg, 75 mg and 100 mg), amitriptyline (50 mg and 75 mg), doxepin (50 mg and 75 mg) and placebo, each of which was administered to 17 healthy volunteers according to a repeated-measures latin square design balanced for drug carry-over.