ENDOMETRIOID CARCINOMA OF THE OVARY - CLINICOPATHOLOGIC, HISTOCHEMICAL, AND ELECTRON-MICROSCOPIC STUDY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (5) , 572-579
Abstract
A material consisting of 23 endometrioid ovarian carcinomas, including 2 rare endometrioid tumors with argyrophil cells, was analyzed clinically and with the use of various histochemical staining methods. EM was performed in 3 cases. Apical neutral mucin mixed with sulfate and carboxyl groups was typical for the cells at the light microscopic level and a prominent Golgi complex with many small secretory vesicles was commonly seen at the ultrastructural level. The nuclei had concentric nuclear bodies and nucleoli with mesh-basket appearance. There was a positive correlation between the grade of differentiation and clinical stage. The corrected 5 yr survival rate was 80% in stage I, 50% in stage II, 17% in stage III and 0% in stage IV. The overall 5 yr survival rate was 46%. Signs of increased endometrial estrogen activity were found in 6 of the 12 postmenopausal patients. In the whole series, 6 endometrial carcinomas were found simulataneously with the ovarian carcinoma.