Ferrocenylphosphines as New Catalysts for Baylis−Hillman Reactions
- 8 October 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (24) , 10175-10177
- https://doi.org/10.1021/jo051701n
Abstract
[reaction: see text] Readily available ferrocenyldialkylphosphines are effective air-stable catalysts for Baylis-Hillman reaction between aldehydes and acrylates, affording the corresponding adducts in high yields and short reaction times. A set of readily accessible planar chiral ferrocenyldialkylphosphines have been tested in asymmetric Baylis-Hillman reactions. The best enantioselectivities were obtained using Mandyphos as chiral catalyst (up to 65% ee).Keywords
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