Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection
- 25 April 2006
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 66 (8) , 1255-1257
- https://doi.org/10.1212/01.wnl.0000208433.34723.65
Abstract
Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor α (TNF-α), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-α) and putamen (hematocrit).Keywords
This publication has 10 references indexed in Scilit:
- Neurological complications of HIV infectionThe Lancet Neurology, 2005
- Disease burden in HIV-associated cognitive impairmentNeurology, 2004
- Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementiaNeurology, 2004
- A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to ageNeuroImage, 2004
- Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementiaJournal of NeuroVirology, 2004
- HIV-1 infection and AIDS dementia are influenced by a mutantMCP-1allele linked to increased monocyte infiltration of tissues and MCP-1 levelsProceedings of the National Academy of Sciences, 2002
- HIV Infection and DementiaScience, 2000
- β‐Chemokines MCP‐1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus–associated dementiaAnnals of Neurology, 1998
- Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementiaProceedings of the National Academy of Sciences, 1998
- Microstructural and Physiological Features of Tissues Elucidated by Quantitative-Diffusion-Tensor MRIJournal of Magnetic Resonance, Series B, 1996