Cardiovascular Responses to Norepinephrine in Acute Adrenal Insufficiency.

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Abstract
Cardiovascular responses to norepinephrine were studied in adrenalectomized (2 days postoperatively) and control dogs. The initial mean systolic and diastolic blood pressures of the adrenalectomized group in both femoral and pulmonary arteries were lower than those of the control group. There was no significant difference between the 2 groups in ability to respond to intravenously injected norepinephrine (0.1-5.0 [mu]g/k ) by an increase in force of cardiac contraction or by an increase in systemic or pulmonary blood pressure. Myocardial or coronary artery lesions did not occur in the 2 adrenalectomized animals examined.