IGE LEVELS IN HODGKINS-DISEASE
- 1 January 1976
- journal article
- research article
- Vol. 37 (6) , 416-419
Abstract
Serum IgE [immunoglobulin E] levels were determined in a retrospectively selected group of 37 patients with Hodgkin''s disease. IgE was determined by a double-antibody radioimmunoassay and expressed as international units per milliliter. Patients were analyzed by stage and histologic classification of disease and compared to 102 normal controls. IgE levels for the total group with Hodgkin''s disease were significantly higher (P = .02) than controls but there was considerable overlap in ranges. IgE elevation was significant in nodular sclerosing (P = .005) and stage II Hodgkin''s disease (P = .0025). IgE elevations seen in other stages and histologic classes were not significant. The IgE elevations are consistent with a suppressor T [thymus-derived] cell dysfunction in Hodgkin''s disease.This publication has 6 references indexed in Scilit:
- Hodgkin's DiseaseAnnals of Internal Medicine, 1967
- Lymphocyte response to phytohemagglutinin in Hodgkin's disease, lymphatic leukemia and lymphosarcomaCancer, 1966
- Immunologic status of Hodgkin's diseaseCancer, 1966
- A Method of Trace Iodination of Proteins for Immunologic StudiesInternational Archives of Allergy and Immunology, 1966
- Impaired in Vitro Lymphocyte Transformation in Hodgkin's DiseaseNew England Journal of Medicine, 1965
- AN INVESTIGATION OF HODGKIN'S DISEASE WITH RESPECT TO THE PROBLEM OF HOMOTRANSPLANTATION *Annals of the New York Academy of Sciences, 1960