Alkali-labile Sites and Post-irradiation Effects in Gamma-irradiated Biologically Active Double-stranded DNA in Aqueous Solution
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 36 (3) , 241-247
- https://doi.org/10.1080/09553007914551011
Abstract
Gamma-irradiation of double-stranded RF-DNA of bacteriophage ϕX174 in aqueous solution in the presence of oxygen produces at least one type of alkalilabile site. It is lethal and gives rise to breaks by alkali and is identical with the damage which becomes manifest by post-irradiation heat treatment. The effect of alkali is dependent on temperature. Furthermore, the excision repair system is not involved in eliminating lethal nucleotide damage in RFI-DNA.This publication has 9 references indexed in Scilit:
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- Monophosphate End Groups Produced in Radiation-Induced Strand Breakage in DNARadiation Research, 1977
- Formation of 5,6-dihydroxydihydrothymine-type Products in DNA by Hydroxyl RadicalsInternational Journal of Radiation Biology, 1977
- End group determination in γ-irradiated DNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
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- Preparation of double-stranded DNA (replicative form) of bacteriophage ΦX174: A simplified methodBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966