Stimulation of DNA synthesis in mouse cell line 3T3 by Simian virus 40.
- 1 October 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (4) , 1170-1176
- https://doi.org/10.1073/pnas.56.4.1170
Abstract
We have investigated nucleic acid production during the early stages of transformation of 3T3 cells by SV40 virus. A stimulation of DNA synthesis was observed at 16-24 hr after infection. The nucleic acid homology studies demonstrated that: (1) most of the newly synthesized DNA was of host cell origin, and (2) viral DNA persisted up to 32 hr after infection and replicated to a very limited extent.Keywords
This publication has 21 references indexed in Scilit:
- DNA synthesis in rat embryo cells infected with polyoma virusVirology, 1966
- Transformation of mouse cell line 3T3 by SV40: Dose response relationship and correlation with SV40 tumor antigen productionVirology, 1966
- High frequency of SV40 transformation of mouse cell line 3T3Virology, 1966
- The initiation of cell division in a contact‐inhibited mammalian cell lineJournal of Cellular and Comparative Physiology, 1965
- The purification of simian virus 40Virology, 1964
- DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCEThe Journal of Experimental Medicine, 1964
- An assay for cellular transformation by SV40Virology, 1964
- TRANSFORMATION OF PROPERTIES OF AN ESTABLISHED CELL LINE BY SV40 AND POLYOMA VIRUSProceedings of the National Academy of Sciences, 1964
- A method for the detection of RNA-DNA complexesBiochemical and Biophysical Research Communications, 1963
- Host specificity of DNA produced by Escherichia coliJournal of Molecular Biology, 1962