Role of RGM coreceptors in bone morphogenetic protein signaling
Open Access
- 5 July 2007
- journal article
- Published by Journal of Molecular Signaling in Journal of Molecular Signaling
- Vol. 2 (1) , 4
- https://doi.org/10.1186/1750-2187-2-4
Abstract
The repulsive guidance molecule (RGM) proteins, originally discovered for their roles in neuronal development, have been recently identified as co-receptors in the bone morphogenetic protein (BMP) signaling pathway. BMPs are members of the TGFβ superfamily of signaling cytokines, and serve to regulate many aspects of cellular growth and differentiation.Keywords
This publication has 41 references indexed in Scilit:
- Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic AnalysesJournal of Biological Chemistry, 2005
- Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptorJournal of Biological Chemistry, 2005
- Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin.2004
- Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosisBlood, 2004
- Mechanisms of TGF-β Signaling from Cell Membrane to the NucleusCell, 2003
- Cripto forms a complex with activin and type II activin receptors and can block activin signalingProceedings of the National Academy of Sciences, 2003
- Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the HeartScience, 1999
- Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β SuperfamilyJournal of Biological Chemistry, 1999
- Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1geneThe EMBO Journal, 1998
- Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells.Endocrinology, 1992