β-1,2-Mannosylation of Candida albicans Mannoproteins and Glycolipids Differs with Growth Temperature and Serotype
Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (9) , 5274-5278
- https://doi.org/10.1128/iai.70.9.5274-5278.2002
Abstract
Increasing the growth temperature from 28 to 37°C reduced the expression of β-1,2-oligomannoside epitopes on mannoproteins of Candida albicans serotypes A and B. In contrast, β-1,2-mannosylation of phospholipomannan (PLM) remained constant despite a slight decrease in the relative molecular weight ( M r ) of this compound. At all growth temperatures investigated, serotype A PLM displayed an M r and an antigenicity different from those of serotype B PLM when they were tested with a panel of monoclonal antibodies.Keywords
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