EFFECT OF DIETARY-FAT ON PULMONARY ENZYMES AND TOXICITY DURING NORMOBARIC HYPEROXIA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 53  (7) , 629-632
Abstract
Weanling male rats were fed a semipurified diet containing 10, 20, 40 or 60% of calories as fat and having a constant polyunsaturated/saturated fatty acid ratio of 0.7. After 21-28 d [day] of feeding, animals from each treatment group were exposed to pure O2 at 2 atm absolute for up to 72 h. Some animals were sacrificed after 0 or 48 h of O2 exposure and lung tissue analyzed for the activities of the hexose monophosphate shunt and prostaglandin dehydrogenase/reductase. Other animals were exposed to hyperoxia until death. With increasing dietary fat content, the preexposure activities of the 2 enzymes decreased and O2-induced mortality increased. There was no dietary effect on enzyme activities after 48 h of hyperoxia. Both dietary fat content and the preexposure activity of prostaglandin dehydrogenase/reductase influenced the relative susceptibility to pulmonary oxygen poisoning.