Toxicokinetics
- 1 January 1978
- book chapter
- Published by Springer Nature
- No. 1,p. 55-67
- https://doi.org/10.1007/978-3-642-66896-8_6
Abstract
The absorption, distribution and elimination of toxic compounds can be described by means of kinetic parameters such as used in pharmacology. Administration of toxic doses may lead to changes in some of these parameters. The toxic effect may further influence the known parameters of some test substances. Toxicokinetic parameters will be described using examples from two groups of compounds 1) naturally occurring toxic compounds and 2) synthetic compounds. Changes in elimination parameters caused by toxic substances will be demonstrated a.o. the effect of long term intake of ochratoxin A and methoxyethyl mercury on the kidney function in swine. In both examples are demonstrated a pronounced reduction in the clearances of inulin and para-aminohippuric acid. Furthermore, an elucidation of concentration dependent changes in enzyme activity and changes in metabolism of pesticides will be given. As examples alkylphosphates and dinitrophenols in domestic animals will be used.Keywords
This publication has 4 references indexed in Scilit:
- Methoxyethyl Mercury Toxicity in Pigs: Kidney Function and Mercury DistributionActa Pharmacologica et Toxicologica, 1976
- The metabolism of methoxyethylmercury saltsBiochemical Journal, 1971
- Metabolism of Methyl Mercury (203Hg) Compounds in ManArchives of environmental health, 1969
- The Kinetics of Alcohol Elimination in Man.Acta Pharmacologica et Toxicologica, 1958