Measurement of Serum Theophylline Concentrations Using a Modified Ames TDA® System

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Abstract
Results are presented which show that the Ames TDA® Theophylline kit provides an accurate and reliable method of measuring the concentration of theophylline in plasma. It may be used with a shortened incubation time (5 min) without loss of accuracy, and a single calibration curve can be used over a 3-week period. There is an acceptable precision at all assayed levels (coefficient of variation, 3.3%) and results obtained for patients' samples correlate well with those obtained using liquid chromatography (y = 0.02 + l.06x, r = 0.99) and enzyme immunoassay (y = 0.58 + 1.03x, r = 0.99).