Commingling in the Distributions of Immunoglobulin Levels

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Abstract
Commingling in the distributions of five immunoglobulins from a Canadian sample of 810 Caucasians and IgE from a US sample of 935 Caucasian was investigated. For both the Canadian and US samples significant comminglingly was found in the child''s but not the adult''s IgE distribution. Contrary to expectations based upon the major gene hypothesis for IgM, we found no evidence for commingling in the IgM distribution. Finally, the distributions of IgA, IgD and IgG all evidenced significant commingling that may the result of a single effect or the operation of a discrete environmental effect.