The IGF‐1 receptor in cancer biology
Top Cited Papers
- 18 September 2003
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 107 (6) , 873-877
- https://doi.org/10.1002/ijc.11487
Abstract
The type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF‐1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.Keywords
This publication has 53 references indexed in Scilit:
- Role of the IGF‐I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progressionJournal of Cellular Physiology, 2002
- Nuclear Translocation of Insulin Receptor Substrate-1 by Oncogenes And Igf-IJournal of Biological Chemistry, 2002
- Expression of an IGF‐I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cellsInternational Journal of Cancer, 2002
- TFIIH Plays an Essential Role in RNA Polymerase I TranscriptionCell, 2002
- Directed Proteomic Analysis of the Human NucleolusCurrent Biology, 2002
- The contradictions of the insulin-like growth factor 1 receptorOncogene, 2000
- The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I ReceptorJournal of Biological Chemistry, 1997
- Co-operation of Simian virus 40 T antigen and insulin receptor substrate-1 in protection from apoptosis induced by Interleukin-3 withdrawalOncogene, 1997
- Growth in size and cell DNA replicationExperimental Cell Research, 1984
- Cell division from a genetic perspectiveThe Journal of cell biology, 1978