β-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture
- 1 September 1985
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 9 (9) , 783-789
- https://doi.org/10.1016/0309-1651(85)90096-7
Abstract
Present studies in the mammary epithelial cell transformation model in organ culture showed that presence of .beta.-carotene during the 24 hr treatment (initiation stage) of the glands with the carcinogens, 7,12-dimethylbenz[a]anthracene (DMBA), N-nitrosodiethylamine (DENA) and N-methylnitrosourea (MNU), caused a highly significant (P < 0.001-0.01) reduction of SCE [sister chromatid exchange] induced by the same carcinogens. In contrast, 4-hydroxyphenylretinamide (4-HPR) which is known to act at the promotional stage of carcinogenesis did not show any significant reduction of SCE. Thus findings suggest that .beta.-carotene can modify the DNA damage effect of the carcinogens and thereby may also prevent the initiation of the carcinogenic process.This publication has 11 references indexed in Scilit:
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