The Relative Biological Effectiveness of Fast Neutrons in Mice

Abstract
Research and Development Technical Report USNRDL-TR-20, NM 006 015. 17 November 1954 [long dash]The 60-inch Crocker Laboratory cyclotron was used to irradiate mice with a neutron beam of 9 Mev mean energy, with 93 per cent of the neutron population between approximately 3 and 20 Mev. The relative biological effectiveness (RBE) of the fast neutrons, compared to 250 KVP X-rays, was determined using reduction of spleen, thymus, and gut weights, and mortality as biological end points. RBE values obtained for these end points were 1.7, 1.5, 2.3, and 1.6, respectively. The results compare closely with those obtained by other investigators using monochromatic 14 Mev neutrons, thus indicating that probably no marked variation in RBE over the high energy neutron range employed exists for the test systems employed.

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