Inhaled corticosteroids and bone mineral density at school age: A follow‐up study after early childhood wheezing

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Abstract
Summary: Objective: The aim of the study was to evaluate the association between previous use of ICS and bone mineral density (BMD) at school age in a cohort followed after early childhood wheezing.Methods: As part of a prospective follow‐up study after hospitalization for wheezing at 6 months at age areal and aBMDvol of the femoral neck were associated with higher cumulative doses of ICS at age 0–12.3 (median) years. The results were robust to adjustment for age, sex, pubertal stage, height, weight, and use of systemic steroids.Conclusion: ICS use during childhood may be related to a decrease in BMD at late school age. It is important to use the lowest possible ICS dose that maintains adequate asthma control. Pediatr Pulmonol. 2015; 50:1–7.
Funding Information
  • Tampere Tuberculosis Foundation
  • North-Karelia Central Hospital, Joensuu, Finland
  • The National Graduation School of Clinical Investigations