Construction of a versatile high precision ambient ionization source for direct analysis and imaging
- 1 October 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 19 (10) , 1527-1534
- https://doi.org/10.1016/j.jasms.2008.06.013
Abstract
The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) are described in full detail, including a complete parts list. The computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis of peptides and proteins ranging from 1 to 17 kDa. The high stability ionization source platform described herein demonstrates both the advantages of the new MALDESI source and versatility for application to numerous desorption and ionization techniques.Keywords
This publication has 31 references indexed in Scilit:
- Ambient Aerodynamic Ionization Source for Remote Analyte Sampling and Mass Spectrometric AnalysisAnalytical Chemistry, 2008
- Probing the mechanisms of an air amplifier using a LTQ-FT-ICR-MS and fluorescence spectroscopyJournal of the American Society for Mass Spectrometry, 2007
- Using Electrospray-Assisted Laser Desorption/Ionization Mass Spectrometry To Characterize Organic Compounds Separated on Thin-Layer Chromatography PlatesAnalytical Chemistry, 2007
- Remote mass spectrometric sampling of electrospray- and desorption electrospray-generated ions using an air ejectorJournal of the American Society for Mass Spectrometry, 2007
- Electrospray‐assisted laser desorption/ionization and tandem mass spectrometry of peptides and proteinsRapid Communications in Mass Spectrometry, 2007
- Characterization of the chemical components on the surface of different solids with electrospray‐assisted laser desorption ionization mass spectrometryRapid Communications in Mass Spectrometry, 2007
- Direct characterization of intact polypeptides by matrix‐assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometryRapid Communications in Mass Spectrometry, 2007
- Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparationChemical Communications, 2006
- Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient ConditionsAnalytical Chemistry, 2005
- Incorporation of a Venturi Device in Electrospray IonizationAnalytical Chemistry, 2003