HISTOLOGIC EFFECTS INDUCED IN THE ANTERIOR PITUITARY OF THE RAT BY PROLONGED INJECTION OF ESTRIN WITH PARTICULAR REFERENCE TO THE PRODUCTION OF PITUITARY ADENOMATA1

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Abstract
The pituitaries of 37 rats receiving injs. of estrin for periods of from 30 to 425 days were studied. In rats treated for the shorter periods such injs. induced a marked but uniform hypertrophy of the gland, but in rats injected for prolonged periods adenomata were induced. Histologically, it was found that the initial reaction to injs. of estrin was generalized. The chromo- philic cells were markedly degranulated and reduced in no., while the chromophobes were increased in size and no. There was hypertrophy of the Golgi apparatus. Three types of adenomata were described. A vacuolar condition of the ant. lobe cells was described. Mitotic figures were generally more abundant in rats injected for shorter periods.