EFFECT OF REPLACEMENT OF L-ALANINE RESIDUE BY GLYCINE, L-SERINE OR D-ALANINE IN AN N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE ON IMMUNOADJUVANCIES OF MOLECULES
- 1 January 1977
- journal article
- research article
- Vol. 20 (2) , 39-45
Abstract
Substitution of the L-alanine residue by L-serine and glycine in an N-acetylmuramyl-L-alanyl-D-isoglutamine, the minimum structural unit essential to the immunoadjuvancies characteristic of bacterial cell wall peptidoglycans, brought about significant increase and some decrease, respectively, in the adjuvant abilities of molecules to induce delayed-type hypersensitivity and to stimulate serum antibody levels to ovalbumin when administered to guinea pigs as a water-in-mineral oil emulsion. N-Acetylmuramyl-D-alanyl-D-isoglutamine was adjuvant-inactive.This publication has 6 references indexed in Scilit:
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