Antibacterial Activity of HR-756, Cefoxitin and Cefuroxime against Multiply Antibiotic-Resistant Strains of Enterobacteriaceae and Pseudomonas aeruginosa

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Abstract
The in vitro antibacterial activity of HR-756 was compared to cefoxitin and cefuroxime. 122 multiresistant clinical isolates including Enterobacteriaceae (104) and P. aeruginosa (18), which present particular problems in antibiotic chemotherapy, were selected for study. HR-756 inhibited all the strains of S. marcescens, P. mirabilis and indole-positive Proteus spp. at a concentration of 1,3 and 12 μg/ml, respectively; β-lactamase-producing strains were also susceptible. 90% of K. pneumoniae and more than half of the Enterobacter and P. aeruginosa were inhibited from the drug at a concentration of 16 μg/ml. Cefoxitin and cefuroxime were less active than HR-756. Cefoxitin was more effective against S. marcescens and P. mirabilis while the same was the case with cefuroxime against K. pneumoniae strains. The greater efficiency of HR-756 over cefoxitin and cefuroxime against these multiply resistant isolates seems to be due not only to its indifference to the β-lactamases but also to its easier penetrability into the bacterial cell.