Hypotensive Activity of Natural and Synthetic Estrogens in Metacorticoid Hypertensive Rats

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Abstract
Five estrogens were tested for hypotensive activity 2,4, and 6 hours after injection into a total of 40 rats, which were compared to solvent-injected controls. All caused a significant lowering of blood pressure, but the 2 synthetic compounds were most active, one of them reducing pressure to the normotensive range. The compounds, in order of decreasing potency, were 16-epiestriol 3-methyl ether, 16-oxoestradiol 3-methyl ether, estriol, estradiol and estrone. These potencies were not correlated with the metrotrophic, osteotrophic, or lipemic potencies.