Meningitis Due to Beta-Lactamase-Producing Haemophilus influenzae: Successful Treatment with Cefuroxime

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Abstract
The clinical efficacy and pharmacokinetics of cefuroxime were studied in 3 children aged 5, 7 and 10 mo. who were suffering from meningitis due to H. influenzae group b (.beta.-lactamase producers). The MIC [minimal inhibitory concentrations] of chloramphenicol against these 3 .beta.-lactamase-producing H. influenzae isolates were 8, 3.1 and 16 .mu.g/ml, respectively; those of cefuroxime were 0.25, 0.5 and 0.12 .mu.g/ml, respectively. The dosage of cefuroxime was 100 mg/kg per day divided in four 6-hourly i.v. doses for 15 days and 10 mg given intrathecally every 48 h. Blood and spinal fluid levels were determined by a microbiological assay. All the children had excellent clinical and bacteriological responses with negative spinal fluid cultures after 48 h of treatment.

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