Modifying Effect of Linoleic Acid on Articular Aging and Osteoarthrosis in Lard-Fed Mice

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Abstract
In the kneejoints of male mice of strain C 57BL Jax6, a dietary supplement of 3% linoleic acid partly reversed the injurious effect caused by a lard-enriched ration not containing un-saturated fatty acids. The incidence of osteoarthrosis which was almost tripled by consumption of the lard-enriched diet, was only insignificantly increased above the spontaneous level in mice given the linoleic acid supplement. There was no correlation between the gain in body weight and the incidence of joint disease. However, while the mice fed the lard-enriched diet suffered considerable weight loss in middle age, those consuming the linoleic acid diet held their weights at near normal levels. It is concluded that the beneficial effect of linoleic acid on the injurious action exerted by a lard-enriched diet on the articular tissues is basically comparable to corresponding observations in non-skeletal tissues.